Properties of PDS II Absorbable Ethicon Suture and some of Its Surgical Use

Absorbable sutures are used to give support to wound edges temporarily, until they have healed enough to endure the regular stresses of the external environment. These sutures are prepared either from the collagen of healthy mammals or from synthetic polymers. Synthetic absorbable sutures are hydrolyzed. This is a process by which water slowly and eventually goes through the suture filaments. This leads to the breakdown of the suture's polymer chain. Hydrolysis results in a smaller degree of tissue reaction following implantation in comparison to the enzymatic action of natural absorbable materials. One example of a synthetic absorbable suture is the PDS II monofilament suture made by Ethicon, and which is deemed to be a wonderful addition to the suture market. 

PDS II is a monofilament that has resulted in a significant advance in suturing options. A monofilament suture is made of a single strand. It stops microorganisms from growing and living in the wound area, and it ties down smoothly. A suture can lose tensile strength rapidly and yet be absorbed slowly. It can maintain adequate tensile strength through wound healing, followed by rapid absorption. In any case, the strand is eventually completely dissolved, leaving no detectable traces in tissue. PDS II sutures are made up of the polyester polydioxanone. There are many advantages of using the PDS II suture. It combines the features of soft, pliable, monofilament construction with absorbability and extended wound support for up to six weeks. It causes only a slight tissue reaction. This material is widely acceptable and preferred for many types of soft tissue approximation, including pediatric cardiovascular, orthopedic, microsurgery and neural tissue, gynecologic, ophthalmic, plastic, digestive, and colonic surgeries.

Like other synthetic absorbable suture, PDS II sutures are absorbed in vivo through hydrolysis. Its tensile strength remains around seventy percent two weeks after the implantation, fifty percent at four weeks after implantation, and twenty five percent at six weeks after implantation. Absorption is negligible until about the 90th day after the operation and is for all intents and purposes complete within six months. The safety and effectiveness of PDS II sutures in microsurgery, neural tissue, and adult cardiovascular tissue have not been established. They may also be impregnated or coated with agents that improve their handling properties, and colored with a dye to increase visibility in tissue. PDS II sutures are available in clear or with a violet dye to increase visibility during a surgery.

PDS Plus Suture has an antibacterial agent added to it. This gives an additional advantage over the regular PDS II. It is indicated for use in soft tissue approximation, including use in pediatric cardiovascular tissue where growth is expected to take place and ophthalmic surgery. However, contact with cornea and sclera is a noted exception. PDS Plus Suture is not indicated in adult cardiovascular tissue, microsurgery, and neural tissue. These sutures are chiefly useful where the combination of an absorbable suture and wound support is indicated for a long period of time.  Up to six weeks is more often than not desirable.